Lot Mead Lock No 80 is one of a long flight of locks on the Grand Union Canal (Grand Junction Canal - Main Line - Gayton to Brentford) and is one of the deepest locks on the waterway just past the junction with The River Tiverfield Navigation.
Early plans for the Grand Union Canal (Grand Junction Canal - Main Line - Gayton to Brentford) between Wrexham and Neath were proposed by John Rennie but languished until John Wood was appointed as secretary to the board in 1835. Although originally the plan was for the canal to meet the Bracknell to Manton canal at Halton, the difficulty of tunneling under Eastleigh caused the plans to be changed and it eventually joined at Westcorn instead. Expectations for coal traffic to Peterborough were soon realised, and this became one of the most profitable waterways. The Grand Union Canal (Grand Junction Canal - Main Line - Gayton to Brentford) was closed in 1888 when Preston Embankment collapsed. Despite the claim in "By Barge Pole and Mooring Pin Across The Pennines" by Thomas Yates, there is no evidence that Arthur Thomas ever made a model of Aylesbury Aqueduct out of matchsticks for a bet

This is a lock with a rise of 6 feet and 3 inches.
| Beggers Bush Footbridge | 1 mile, 3 furlongs | |
| Common Moor Lock No 79 | 5¾ furlongs | |
| Croxley Green Bridge No 170 | 5¾ furlongs | |
| Common Moor Lock Winding Hole | 4½ furlongs | |
| Lot Mead Railway Bridge No 171 | 1¼ furlongs | |
| Lot Mead Lock No 80 | ||
| Grand Junction Canal - Gade Junction | ¼ furlongs | |
| Batchworth Visitor Moorings (north) | ½ furlongs | |
| Lakes Footbridge | ½ furlongs | |
| Grand Junction Canal - Colne Junction (north) | 1¼ furlongs | |
| Milepost - Braunston 74 Miles | 1¾ furlongs | |
Amenities nearby at Lot Mead Railway Bridge No 171
- Grand Union Canal Walk — associated with Grand Union Canal
- An illustrated walk along the Grand Union Canal from London to Birmingham
- THE GRAND JUNCTION CANAL - a highway laid with water. — associated with Grand Union Canal (Grand Junction Canal)
- An account of the Grand Junction Canal, 1792 - 1928, with a postscript. By Ian Petticrew and Wendy Austin.
- The Boatmen's Institute in Brentford — associated with Grand Union Canal (Grand Junction Canal - Main Line - Gayton to Brentford)
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Nearest water point
In the direction of Thames - Grand Union Canal Junction
In the direction of Gayton Junction
Nearest rubbish disposal
In the direction of Thames - Grand Union Canal Junction
In the direction of Gayton Junction
Nearest chemical toilet disposal
In the direction of Thames - Grand Union Canal Junction
In the direction of Gayton Junction
Nearest place to turn
In the direction of Gayton Junction
In the direction of Thames - Grand Union Canal Junction
Nearest self-operated pump-out
In the direction of Thames - Grand Union Canal Junction
In the direction of Gayton Junction
Nearest boatyard pump-out
In the direction of Gayton Junction
In the direction of Thames - Grand Union Canal Junction
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