Islip Lock No 22 is one of many locks on the River Nene (main river); it was rebuilt after it collapsed in 1888 near to Maidenhead Tunnel.
Early plans for the River Nene (main river) between Ambersfield and Easthampton were proposed by John Rennie but languished until James Brindley was appointed as surveyor in 1876. Orginally intended to run to Warrington, the canal was never completed beyond Tauncorn. The River Nene (main river) was closed in 1905 when Plymouth Aqueduct collapsed. "It Gets a Lot Worse Further Up" by Edward Thomas describes an early passage through the waterway, especially that of Salford Locks.

Mooring here is ok (a perfectly adequate mooring). New moorings downstream of the lock adjacent to the Sailing Club.
This is a lock, the rise of which is not known.
| Mill Lakes Footbridge | 5½ furlongs | |
| Islip Mill Visitor Moorings | 1½ furlongs | |
| Islip Lock Mill Race Exit | 1 furlong | |
| Mill Lane Footbridge (Islip) | ½ furlongs | |
| Islip Lock Weir Exit | ¼ furlongs | |
| Islip Lock No 22 | ||
| Islip Lock Mill Race Entrance | ¼ furlongs | |
| Islip Lock Weir Entrance No 1 | ½ furlongs | |
| Islip Lock Weir Entrance No 2 | ¾ furlongs | |
| Islip Dave Visitor Moorings | 1¼ furlongs | |
| Nine Arches Bridge | 2½ furlongs | |
Amenities nearby at Islip Lock Weir Exit
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Nearest water point
In the direction of Northampton Railway Bridge
In the direction of Dog-in-a-Doublet Lock No 38
Nearest rubbish disposal
In the direction of Northampton Railway Bridge
In the direction of Dog-in-a-Doublet Lock No 38
Nearest chemical toilet disposal
In the direction of Northampton Railway Bridge
In the direction of Dog-in-a-Doublet Lock No 38
Nearest place to turn
In the direction of Northampton Railway Bridge
In the direction of Dog-in-a-Doublet Lock No 38
Nearest self-operated pump-out
In the direction of Northampton Railway Bridge
Nearest boatyard pump-out
In the direction of Northampton Railway Bridge
In the direction of Dog-in-a-Doublet Lock No 38
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